Used Mercedes E-Class Models Compared

The 2018 Mercedes E300 and 2020 E350 are two used E-Class sedans with a strong track record. 0-liter turbo four-cylinder engine. The 2018 E300 is lighter and more aerodynamic, resulting in better fuel economy. The 2020 E350 received a mild refresh with updated technology, including a larger touchscreen and improved driver-assist features.
However, the 2018 E300 has simpler electronics, which can mean fewer issues down the road. Common problems with these models include the 48-volt mild-hybrid system on the 2020 E350 occasionally throwing a warning light, and clogged panoramic sunroof drains on both years, which can lead to wet carpets.
Regular transmission fluid changes every 40,000 miles are also recommended. A well-maintained 2018 E300 may be a more cost-effective option for those with a budget between $17,000 and $20,000, offering a quiet and reliable ride without the potential for pricier repairs associated with newer electronics.
Source: MBWorld (Mercedes)
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